Professor Linse is Head of Sweden office for Wren Therapeutics and is Professor of Physical Chemistry and Molecular Protein Science at Lund University, Sweden. Her current research focuses on protein misfolding and self-assembly, including the aggregation process, the influence of intrinsic and extrinsic factors, and coaggregation between lipids and proteins.
Professor Linse's research has focused on developing new experimental and theoretical tools for studying highly complex systems of misfolding proteins in a quantitative and repeatable manner. Her approaches have made it possible to generate (for the first time) high signal-to-noise data from these systems, and have subsequently revealed fundamental insights into the molecular mechanisms driving these systems, including the importance of auto-catalytic cycles in the protein misfolding and aggregation pathway.
Professor Linse has received numerous awards for her work, including the Cozzarelli Prize awarded by the National Academy of Sciences, USA (2007), the IUPAC Distinguished Woman in Chemistry prize (2011), and Sweden’s KTH Royal Institute of Technology’s Great Prize (2014). Professor Linse studied Chemical Engineering at Lund University and Stanford University, and received her doctorate in Physical Chemistry from Lund.
In 2009, Professor Linse became a Member of the Nobel Prize Committee for Chemistry; she served as Chair of the Committee from 2015-2017, and continues as a Member of the Committee.
Professor Linse has co-authored over 245 peer-reviewed scientific articles.
Publications by Prof. Sara Linse
Drug discovery | Sep 2020
Kinetic fingerprints differentiate the mechanisms of anti-Aβ antibodies
Linse S, Scheidt T, Bernfur K, Vendruscolo M, Dobson CM, Cohen SI, Sileikis E, Lundquist M, Qian F, O’Malley T, Bussiere T, Weinreb PH, Xu CK, Meisl G, Devenish SR, Knowles TP, Hansson O
Disease Mechanisms | Apr 2020
Determining dynamics during amyloid assembly
Michaels TC, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear AJ, Cohen SI, Dobson CM, Vendruscolo M, Linse S and Knowles TP.
Drug discovery | Oct 2018
SAR by kinetics for drug discovery in protein misfolding diseases
Chia S, Habchi J, Michaels TC, Cohen SI, Linse S, Dobson CM, Knowles TP and Vendruscolo M.
Methods | Jun 2017
Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method
Aprile FA, Sormani P, Perni M, Arosio P, Linse S, Knowles TP, Dobson CM and Vendruscolo M.