Professor Vendruscolo is the Chief Scientific Officer of Wren Therapeutics. He is a Professor of Biophysics and co-director of the Cambridge Centre for Protein Misfolding Diseases at the University of Cambridge.
Professor Vendruscolo's research interests are focused on the investigation of the physico-chemical principles of protein homeostasis and their application to the development of therapeutic strategies against neurodegenerative diseases. His methods offer new insights into the manner in which physics and chemistry regulate the biochemical reactions taking place in living organisms, and have led him to clarify the fundamental role that protein solubility has in the maintenance of protein homeostasis. Professor Vendruscolo has demonstrated how these approaches provide a rational basis for diagnostic and therapeutic strategies to combat some of the most prevalent and still incurable protein misfolding diseases.
Professor Vendruscolo has received several awards for his work, including the Soft Matter & Biophysical Chemistry award from the Royal Society of Chemistry (2013) and the Giuseppe Occhialini Prize from the UK Institute of Physics (2017).
Professor Vendruscolo received his PhD in Condensed Matter Physics in 1996 from the International School for Advanced Studies in Trieste (Italy). He then spent two years as post-doctoral fellow at the Weizmann Institute of Science (Israel), before moving to Oxford, where he worked in collaboration with Chris Dobson. He later moved to Cambridge and was appointed successively as a Royal Society University Research Fellow, a Lecturer, a Reader and a Professor (2010).
Professor Vendruscolo has co-authored over 300 peer-reviewed scientific articles.
Publications by Prof. Michele Vendruscolo
Methods | Jun 2020
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
Aprile FA, Sormanni P, Podpolny M, Chhangur S, Needham L, Ruggeri FS, Perni M, Limbocker R, Heller GT, Sneideris T, Scheidt T, Mannini B, Habchi J, Lee SF, Salinas PC, Knowles TP, Dobson CM and Vendruscolo M.
Disease Mechanisms | Apr 2020
Determining dynamics during amyloid assembly
Michaels TC, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear AJ, Cohen SI, Dobson CM, Vendruscolo M, Linse S and Knowles TP.
Drug discovery | Oct 2018
SAR by kinetics for drug discovery in protein misfolding diseases
Chia S, Habchi J, Michaels TC, Cohen SI, Linse S, Dobson CM, Knowles TP and Vendruscolo M.
Disease Mechanisms | Dec 2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Fusco G, Chen SW, Williamson PT, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM and De Simone A.