Disease Mechanisms | Mar 2017
Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TP, Sparr E and Linse S.
Drug discovery | Feb 2017
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
Perni M, Galvagnion C, Maltsev A, Meisl G, Müller MB, Challa PK, Kirkegaard JB, Flagmeier P, Cohen SI, Cascella R, Chen SW, Limbocker R, Sormanni P, Heller GT, Aprile FA, Cremades N, Cecchi C, Chiti F, Nollen EA, Knowles TP, Vendruscolo M, Bax A, Zasloff M and Dobson CM.
Drug discovery | Jan 2017
Systematic Development of Small Molecules to Inhibit Specific Microscopic Steps of Aβ42 Aggregation in Alzheimer's Disease
Habchi J, Chia S, Limbocker R, Mannini B, Ahn M, Perni M, Hansson O, Arosio P, Kumita JR, Challa PK, Cohen SI, Linse S, Dobson CM, Knowles TP and Vendruscolo M.
Disease Mechanisms | Sep 2016
Structural basis of synaptic vesicle assembly promoted by α-synuclein
Fusco G, Pape T, Stephens AD, Mahou P, Costa AR, Kaminski CF, Kaminski Schierle GS, Vendruscolo M, Veglia G, Dobson CM and De Simone A.
Disease Mechanisms | Jun 2016
Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein
Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E and Dobson CM.
Disease Mechanisms | Mar 2016
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP and Klenerman D.
Drug discovery | Feb 2016
An Anticancer Drug Suppresses the Primary Nucleation Reaction That Initiates the Production of the Toxic Aβ42 Aggregates Linked With Alzheimer's Disease
Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi, Joshi P, Chia S, Cohen SI, Müller MB, Linse S, Nollen EA, Dobson CM, Knowles TP and Vendruscolo M.
Methods | Jul 2015
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
Sormanni P, Aprile FA and Vendruscolo M.