Methods | Jun 2020
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers
Aprile FA, Sormanni P, Podpolny M, Chhangur S, Needham L, Ruggeri FS, Perni M, Limbocker R, Heller GT, Sneideris T, Scheidt T, Mannini B, Habchi J, Lee SF, Salinas PC, Knowles TP, Dobson CM and Vendruscolo M.
Disease Mechanisms | Apr 2020
Determining dynamics during amyloid assembly
Michaels TC, Šarić A, Curk S, Bernfur K, Arosio P, Meisl G, Dear AJ, Cohen SI, Dobson CM, Vendruscolo M, Linse S and Knowles TP.
Drug discovery | Oct 2018
SAR by kinetics for drug discovery in protein misfolding diseases
Chia S, Habchi J, Michaels TC, Cohen SI, Linse S, Dobson CM, Knowles TP and Vendruscolo M.
Disease Mechanisms | Dec 2017
Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers
Fusco G, Chen SW, Williamson PT, Cascella R, Perni M, Jarvis JA, Cecchi C, Vendruscolo M, Chiti F, Cremades N, Ying L, Dobson CM and De Simone A.
Methods | Jun 2017
Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method
Aprile FA, Sormani P, Perni M, Arosio P, Linse S, Knowles TP, Dobson CM and Vendruscolo M.
Drug discovery | Jun 2017
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TP and Linse S.
Protein Misfolding Diseases | Jun 2017
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
Chiti F and Dobson CM.
Disease Mechanisms | Mar 2017
Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TP, Sparr E and Linse S.