A different way of thinking
Folded protein diseases: Individual behaviour
- One target, few states
- Linear, limited feedback
- Structured, stable
Misfolded protein diseases: Network behaviour
- Many targets, many states
- Non-linear, feedback loops
- Disordered, unstable
What is the most effective strategy to reduce toxicity in these complex systems?
Wren has developed an entirely new approach to drug discovery designed specifically to address the unique challenges of protein misfolding. Our kinetics-based approach solves for the molecular reaction network that underlies each misfolding disease, providing a fully predictive, quantitative map of the network and its dynamics. The approach further reveals the most effective strategy to reduce toxicity across the network, which is often highly counter-intuitive, and enables us to rapidly discover and optimise therapeutic drugs.