We are harnessing biophysics to target fleeting intermediates in neurodegenerative disease.

We have invested deeply in research studying the behavior of misbehaving protein pathways—both ordered and disordered behavior—to quantify the rules by which these pathways are regulated. Over two decades of work, we have discovered that the assembly of amyloid plaques is a highly predictable biophysical process, tightly regulated by biophysical and biochemical parameters, quantifiable and mappable with network kinetics.

We are applying these learned rules to design novel medicines to inhibit this neurodegenerative disease process: To block the production of toxic, misbehaving protein forms—specifically, the neurotoxic protein oligomer intermediates produced within this pathway.

The biophysical rules governing amyloid assembly are exquisitely reproducible, allowing us to develop precision assays that express the same dynamic process that occurs in human disease. We are able to replicate the interconnected biochemical network that occurs in the brain, to study a process that previously was hidden from view.

With a deep understanding of the dynamics of protein aggregation assembly, we are mapping the molecular mechanisms that define pathways of protein misfolding and aggregation—from the primary origins in the early stages of disease through the assembly of mature plaques in more advanced disease.

We are applying these dynamic rules of amyloid assembly first for the major neurodegenerative diseases—Alzheimer’s disease, Parkinson’s disease, and ALS—and we will broaden our approach to other diseases beyond neurodegeneration.

WREN PLATFORM

DEFINED
MECHANISMS & RULES

We’ve defined the molecular mechanisms and biophysical rules for the disease process of protein misfolding and aggregation in Alzheimer’s disease, Parkinson’s disease, and ALS

TRANSLATIONAL
PRECLINICAL MODELS

We’ve developerd translational preclinical models from these biophysical rules that express the same highly conserved amyloid assembly processes that occur in human disease

BIOMARKERS FOR
CLINICAL TRIALS

We’re developing biomarkers that measure the on-target effect of our drugs on the progression of the toxic oligomer intermediates in these disease networks in clinical trials

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